Soluble Dextrin Fibers Alter the Intestinal Microbiota and Reduce Proinflammatory Cytokine Secretion in Male IL-10-Deficient Mice.

Rosica ValchevaNaomi HottePatrick GillevetMasoumeh SikaroodiAducio ThiessenKaren L Madsen

Published in: The Journal of nutrition (2015)

These results demonstrate that soluble prebiotic fibers selectively stimulate the growth of a distinctive gut microbiota in IL-10(-/-) mice. SFD-t induced the growth of butyrate-producing microbes and was effective in reducing proinflammatory cytokine secretion and enterocyte injury in this mouse model of colitis.

Keyphrases

mouse model
high glucose
high fat diet induced
adipose tissue
metabolic syndrome
ulcerative colitis
wild type