Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment.

Aleš Kvasnička David Friedecký Radana Brumarová Markéta Pavlíková Kateřina Pavelcová Jana Mašínová Lenka Hasikova Jakub Závada Karel Pavelka Pavel Ješina Blanka Stibůrková

Published in: Arthritis research & therapy (2023)

Alterations in the lipidome of HUA and Gout patients show a significant impact on lipid metabolism. The most significant glycerophospholipid dysregulation was found in HUA ≤ 40 and Gout ≤ 40 patients, together with a correction of this imbalance with ULT.

Keyphrases

early onset
end stage renal disease
uric acid
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
patient reported outcomes