IPSE, an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium, promotes proliferation of bladder cancer cells and angiogenesis.
Evaristus C MbanefoChinwike Terry AgboYuanlong ZhaoOlivia K LamannaKim H ThaiShannon E KarinshakMohammad Afzal KhanChi-Ling FuJustin I OdegaardIrina V SaltikovaMichael J SmoutLuke F PenningtonMark R NicollsTheodore S JardetzkyAlex LoukasPaul J BrindleyFranco H FalconeMichael H HsiehPublished in: Infectious agents and cancer (2020)
Schistosoma haematobium acts as a bladder carcinogen through unclear mechanisms. The S. haematobium homolog of IPSE, a secreted schistosome egg immunomodulatory molecule, enhances angiogenesis and urothelial proliferation, hallmarks of pre-carcinogenesis, suggesting IPSE is a key pro-oncogenic molecule of S. haematobium.