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Therapeutic potential of proteasome inhibitors for dihydropyridine-induced gingival overgrowth.

Sao-Lun LuJui-Hung ChangChiung-Fang HuangSam Li-Sheng Chen
Published in: Oral diseases (2020)
We suggested that IKK-IκBα activation is mediated by proinflammatory cytokines and CCBs in DIGO cells and triggers downstream NF-κB-Col I synthesis. Proteasome inhibitors may strategically interfere with the IKK-IκBα-NF-κB-Col I pathway and inhibit the etiopathogenesis of DIGO.
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