First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child's genetic risk.
Suzanne Bennett JohnsonKristian F LynchRoswith RothMarkus LundgrenHemang M ParikhBeena AkolkarWilliam A HagopianJeffrey P KrischerMarian J RewersJin Xiong SheJorma ToppariAnette-Gabriele ZieglerLernmark Åkenull nullPublished in: Diabetologia (2021)
Specific life events during pregnancy are differentially related to IAA vs GADA as first-appearing IA and interact with different HLA and non-HLA genetic factors, supporting the concept of different endotypes underlying type 1 diabetes. However, the mechanisms underlying these associations remain to be discovered. Life events may be markers for other yet-to-be-identified factors important to the development of first-appearing IA.