VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.

Xiaotong LouQianxue MouBowen ZhaoJingqiu HuangKe YaoZhaoxia LuoMeng YeYuanyuan HuQiming DuanXing LiZheng WenZhiqi ChenHong Zhang Yin Zhao

Published in: Oxidative medicine and cellular longevity (2021)

This study provides insights into the role of VIP in stabilizing the interaction between the actin cytoskeleton and cell junctions and may provide a promising targeted strategy for glaucoma treatment.

Keyphrases

single cell
cell death
cell therapy
single molecule
stem cells
induced apoptosis
drug delivery
mesenchymal stem cells
signaling pathway
combination therapy
endoplasmic reticulum stress
optic nerve