Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies.

Shady Ibrahim Tantawy Aloke Sarkar Stefan E Hubner Zhi Tan William G Wierda Abdelraouf Eldeib Shuxing Zhang Steven Mitchell Kornblau Varsha Gandhi

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

We conclude that MCL-1i blocked Mcl-1 ubiquitination via enhanced deubiquitination and dissociation of Mcl-1 from Noxa, Bak and Bax, and Mule de-stabilization. These are critical events associated with increased Mcl-1 protein stability with AMG-176 and AZD5991.

Keyphrases

protein protein
small molecule
electron transfer