The diagnostic performance of CA-125 for the detection of ovarian cancer in women from different ethnic groups: a cohort study of English primary care data.

Melissa Barlow Liz Down Luke Timothy Allan Mounce Garth Funston Samuel William David Merriel Jessica C Watson Gary A Abel Lucy Kirkland Tanimola Martins Sarah Elizabeth Rose Bailey

Published in: Journal of ovarian research (2024)

The introduction of ethnicity-specific thresholds may increase the specificity and PPVs of CA-125 in ovarian cancer detection at the expense of sensitivity, particularly for Asian and Black women. As such, we cannot recommend the use of ethnicity-specific thresholds for CA-125.

Keyphrases

primary care
polycystic ovary syndrome
loop mediated isothermal amplification
pregnancy outcomes
protein kinase
real time pcr
label free
cervical cancer screening
electronic health record
big data
skeletal muscle