Self-reporting of hearing loss and tinnitus in the diagnosis of ototoxicity by meglumine antimoniate in patients treated for American tegumentary Leishmaniasis.
Claudia Cristina Jardim DuarteTania Salgado de Sousa TorracaDébora de Oliveira BezerraRenata de Barcelos OliveiraNayany Kerollyany Sousa LeiteRaquel de Vasconcellos Carvalhaes de OliveiraMaria Helena Araújo-MeloMaria Inês Fernandes PimentelAnanda Dutra da CostaÉrica de Camargo Ferreira VasconcellosMarcelo Rosandiski LyraEster Cleisla Dos Anjos SoaresLúcia Regina do Nascimento Brahim PaesMariza Mattos SalgueiroArmando de Oliveira SchubachClaudia Maria Valete-RosalinoPublished in: PloS one (2024)
Although the large number of false negatives suggests that self-report of hearing loss or tinnitus cannot be considered a good screening test for referring the patient to an audiometry, the low number of false positives suggests the need to value the patient's complaint for referral. Otherwise, this study reinforces the importance of audiological monitoring during treatment with MA, especially in those patients with self-reporting of hearing loss or tinnitus when treated with 20 mg Sb5+/kg/day via IM.