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Interpretation and approximation tools for big, dense Markov chain transition matrices in population genetics.

Katja ReichelValentin BahierCédric MidouxNicolas PariseyJean-Pierre MassonSolenn Stoeckel
Published in: Algorithms for molecular biology : AMB (2015)
Our methods help to make stochastic population genetic models involving big, dense transition matrices computationally feasible. Our visualization techniques provide new ways to explore such models and concisely present the results. Thus, our methods will contribute to establish state-rich Markov chains as a valuable supplement to the diversity of population genetic models currently employed, providing interesting new details about evolution e.g. under non-standard reproductive systems such as partial clonality.
Keyphrases
  • big data
  • genome wide
  • copy number
  • machine learning
  • dna methylation
  • gene expression