CD4+ effector T cells accelerate Alzheimer's disease in mice.
Jatin MachhiPravin YeapuriYaman LuEmma FosterRupesh ChikhaleJonathan HerskovitzKrista L NammingaKatherine E OlsonMai Mohamed AbdelmoatyJu GaoRolen M QuadrosTomomi KiyotaLiang JingjingBhavesh D KevadiyaXinglong WangYutong LiuLarisa Y PoluektovaChannabasavaiah B GurumurthyR Lee MosleyHoward E GendelmanPublished in: Journal of neuroinflammation (2021)
These results underscore an important pathological role for CD4+ Teffs in AD progression. We posit that aberrant disease-associated effector T cell immune responses can be controlled. One solution is by Aβ reactive Tregs.