Terms and Definitions Used to Describe Recurrence, Treatment Failure and Recovery of Acute Exacerbations of COPD: A Systematic Review of Observational Studies.
Wilhelmine H MeerausBailey M DeBarmoreHana MullerovaWilliam A FahyVictoria S BensonPublished in: International journal of chronic obstructive pulmonary disease (2021)
Our review demonstrates that subsequent AECOPDs (including events such as relapse, recurrence/re-exacerbation, treatment failure, non-recovery/time to recovery) are ill-defined in the observational study literature, emphasizing the need to reach consensus on precise and objective definitions (for example, when one AECOPD ends and another begins). Use of standardized terminology and definitions may aid comparability between, and synthesis of, studies, thus improving the understanding of the natural history and burden of exacerbations in COPD patients.
Keyphrases
- chronic obstructive pulmonary disease
- end stage renal disease
- lung function
- cystic fibrosis
- systematic review
- newly diagnosed
- chronic kidney disease
- liver failure
- free survival
- ejection fraction
- prognostic factors
- intensive care unit
- combination therapy
- peritoneal dialysis
- patient reported outcomes
- risk factors
- air pollution
- clinical practice
- extracorporeal membrane oxygenation
- mechanical ventilation
- acute respiratory distress syndrome