Cell-Type Specific Inhibition Controls the High-Frequency Oscillations in the Medial Entorhinal Cortex.
Shalva GurgenidzePeter BäuerleDietmar SchmitzImre VidaTengis GloveliTamar DugladzePublished in: International journal of molecular sciences (2022)
The medial entorhinal cortex (mEC) plays a critical role for spatial navigation and memory. While many studies have investigated the principal neurons within the entorhinal cortex, much less is known about the inhibitory circuitries within this structure. Here, we describe for the first time in the mEC a subset of parvalbumin-positive (PV+) interneurons (INs)-stuttering cells (STUT)-with morphological, intrinsic electrophysiological, and synaptic properties distinct from fast-spiking PV+ INs. In contrast to the fast-spiking PV+ INs, the axon of the STUT INs also terminated in layer 3 and showed subthreshold membrane oscillations at gamma frequencies. Whereas the synaptic output of the STUT INs was only weakly reduced by a μ-opioid agonist, their inhibitory inputs were strongly suppressed. Given these properties, STUT are ideally suited to entrain gamma activity in the pyramidal cell population of the mEC. We propose that activation of the μ-opioid receptors decreases the GABA release from the PV+ INs onto the STUT, resulting in disinhibition of the STUT cell population and the consequent increase in network gamma power. We therefore suggest that the opioid system plays a critical role, mediated by STUT INs, in the neural signaling and oscillatory network activity within the mEC.
Keyphrases
- high frequency
- chronic pain
- pain management
- transcranial magnetic stimulation
- functional connectivity
- working memory
- single cell
- induced apoptosis
- cell therapy
- spinal cord
- magnetic resonance imaging
- magnetic resonance
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- bone marrow
- cell cycle arrest
- single molecule
- optical coherence tomography
- pi k akt
- network analysis