Folding mutations suppress early beta-cell proliferation.
Honey ModiJames D JohnsonPublished in: eLife (2018)
Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes.
Keyphrases
- cell proliferation
- induced apoptosis
- cell cycle arrest
- signaling pathway
- type diabetes
- cardiovascular disease
- single molecule
- pi k akt
- cell cycle
- glycemic control
- molecular dynamics simulations
- gestational age
- cell death
- endoplasmic reticulum stress
- oxidative stress
- pregnant women
- metabolic syndrome
- adipose tissue
- pregnancy outcomes
- preterm birth