GATA4 downregulation enhances CCL20-mediated immunosuppression in hepatocellular carcinoma.

Nurul Jannah Mohamed NasirSamuel ChuahTimothy Wai Ho ShuenAldo PrawiraRebecca BaMei Chee LimJoelle ChuaPhuong H D NguyenChun J LimMartin WasserSharifah N HazirahTony K H LimWei Qiang LeowTracy Jiezhen LohWei Keat WanYin Huei PangGwyneth SoonPeng Chung CheowJuinn Huar KamShridhar IyerAlfred KowYock Young DanGlenn K BonneyAlexander ChungBrian K P GohPierce K H ChowSalvatore AlbaniWeiwei ZhaiJohn F OuyangHan Chong TohValerie Chew

Published in: Hepatology communications (2024)

Our study reveals that GATA4 downregulation contributes to an immunosuppressive microenvironment, driven by CCL20-mediated enrichment of regulatory T cells and myeloid-derived suppressor cells in HCC. These findings underscore the critical role of GATA4 reduction in promoting immunosuppression and HCC progression.

Keyphrases

regulatory t cells
transcription factor
induced apoptosis
signaling pathway
cell proliferation
dendritic cells
liver fibrosis
liver injury
stem cells
cell cycle arrest
immune response
oxidative stress
pi k akt
endoplasmic reticulum stress