BIBR1532 combined with radiotherapy induces ferroptosis in NSCLC cells and activates cGAS-STING pathway to promote anti-tumor immunity.
Yawei BaoZhipeng PanLuqi ZhaoJieping QiuJingjing ChengLei LiuDong QianPublished in: Journal of translational medicine (2024)
This study underscores the potential of BIBR1532 as an efficacious and safe radiosensitizer and radioimmunotherapy synergist, providing robust preclinical research evidence for the treatment of NSCLC.
Keyphrases
- small cell lung cancer
- induced apoptosis
- advanced non small cell lung cancer
- cell death
- cell cycle arrest
- early stage
- radiation therapy
- brain metastases
- locally advanced
- squamous cell carcinoma
- stem cells
- cell therapy
- signaling pathway
- cell proliferation
- combination therapy
- epidermal growth factor receptor
- climate change