Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
Benjamin K Y ChanMohamed ElmasryShiva S ForootanGiusy RussomannoTobias M BundayFang ZhangNathalie BrillantPhilip Starkey LewisRhona AirdEmanuele RicciTimothy D AndrewsRowena L Sison-YoungAmy L SchofieldYongxiang FangAdam ListerJack W SharkeyHarish PoptaniNeil R KitteringhamStuart John ForbesHassan Z MalikStephen W FenwickB Kevin ParkChristopher E GoldringIan M CopplePublished in: Hepatology (Baltimore, Md.) (2021)
Our results indicate that pharmacological activation of Nrf2 is a promising strategy for enhancing functional liver regeneration. Such an approach could therefore aid the recovery of patients undergoing liver surgery and support the treatment of acute and chronic liver disease.