Exosomes from miR-23 Overexpressing Stromal Cells Suppress M1 Macrophage and Inhibit Calcium Oxalate Deposition in Hyperoxaluria Rat Model.

Zhang YifanZhang ShengliWang MinCheng WenjieSun YiLuwei Xu Ruipeng Jia

Published in: BioMed research international (2023)

In conclusion, our research gave the first evidence that ADSC-derived miR-23-enriched exosomes affected the polarization of M1 macrophages by directly inhibiting IRF1 and protecting against calcium oxalate stone formation in a hyperoxaluria rat model.

Keyphrases

cell proliferation
long non coding rna
mesenchymal stem cells
long noncoding rna
stem cells
signaling pathway
adipose tissue
dendritic cells
immune response
bone marrow