TSPO PET detects acute neuroinflammation but not diffuse chronically activated MHCII microglia in the rat.
Nassir U Al-KhishmanQi QiAustyn D RoseboroughAlexander LevitBrian L AllmanUdunna C AnazodoMatthew S FoxShawn N WhiteheadJonathan Dale ThiessenPublished in: EJNMMI research (2020)
TSPO was only expressed in the stroke-induced insult and proximal tissue and therefore was unable to detect remote and non-insult-related chronically activated microglia overexpressing MHCII in WM. This suggests that research in neuroinflammation, particularly in the WM, would benefit from MHCII-sensitive radiotracers.
Keyphrases
- pet imaging
- inflammatory response
- lipopolysaccharide induced
- lps induced
- drug induced
- cerebral ischemia
- traumatic brain injury
- neuropathic pain
- liver failure
- cognitive impairment
- high glucose
- atrial fibrillation
- diabetic rats
- respiratory failure
- oxidative stress
- computed tomography
- positron emission tomography
- pet ct
- low grade
- spinal cord
- spinal cord injury
- intensive care unit
- blood brain barrier
- hepatitis b virus
- extracorporeal membrane oxygenation
- stress induced
- acute respiratory distress syndrome
- mechanical ventilation