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Reference genome and comparative genome analysis for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine.

Katlyn BorgersJheng-Yang OuPo-Xing ZhengPetra TielsAnnelies Van HeckeEvelyn PletsGitte MichielsenNele FestjensNico CallewaertYao-Cheng Lin
Published in: BMC genomics (2019)
We demonstrate how this analysis workflow enables the resolution of genome duplications and of the genome of engineered derivatives of the BCG Danish vaccine strain. The BCG Danish WHO reference genome will serve as a reference for future engineered strains and the established workflow can be used to enhance BCG vaccine standardization.
Keyphrases
  • genome wide
  • mycobacterium tuberculosis
  • escherichia coli
  • emergency department
  • electronic health record
  • single molecule
  • current status
  • hiv infected