Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced Pulmonary Hypertension Through ER Stress and Redox-Sensitive Pathways.
Hannah E MorrisKarla Bianca NevesMargaret NilsenAugusto C MontezanoMargaret R MacLeanRhian M TouyzPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Notch3 GOF amplifies vascular dysfunction in hypoxic PH. This involves oxidative and ER stress, and ROCK. We highlight a novel role for Notch3/Hes5-redox signaling and important interplay between ER and oxidative stress in PH.