Hot topics in renal cancer pathology: implications for clinical management.

Pathologist assessment of prognostic features suffer from interobserver variability which may depend on gross sampling and the pathologist's expertise. The presence of clear cell feature is not sufficient criteria by itself to define ccRCC since clear cell can be also found in other histotypes. Moreover, the awareness of other morphological parameters such as architectural patterns may help pathologists in tumor grading. Application of molecular biomarkers may be useful tools in the near future to help clinicians identify patients harboring tumors with worse prognosis.