Effect of flecainide on atrial fibrillatory rate in a large animal model with induced atrial fibrillation.

Eva Z HesselkildeHelena CarstensenMaria M HaugaardJonas CarlsonSteen PehrsonThomas JespersenRikke BuhlPyotr G Platonov

Published in: BMC cardiovascular disorders (2017)

AFR in horses with induced AF resembles AFR in humans with paroxysmal AF. Flecainide caused a rapid decrease in AFR in all horses, further supporting the method to be a non-invasive technique to study the effect of antiarrhythmic compounds.

Keyphrases

atrial fibrillation
catheter ablation
left atrial
high glucose
oral anticoagulants
left atrial appendage
diabetic rats
direct oral anticoagulants
drug induced
heart failure
endothelial cells
percutaneous coronary intervention
oxidative stress
venous thromboembolism
acute coronary syndrome