Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress.

The growing burden of obesity and diabetes drives an increasing portion of atherosclerotic cardiovascular disease, and represents a major challenge to public health. Herein, we probe the efficacy of recombinant SIRT1 supplementation to preserve endothelial function and vascular compliance during diabetic conditions. Notably, SIRT1 levels were diminished in diabetic arteries of mice and humans alike, while recombinant SIRT1 delivery improved energy metabolism and vascular function by suppressing oxidative stress. Our study deepens mechanistic insights into the vasculo-protective effects conferred by recombinant SIRT1 supplementation and opens therapeutic avenues to mitigate vascular disease in diabetic patients.