Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica.
Tao FengKai-Ting DuanShi-Jun HeBin WuYong-Sheng ZhengHong-Lian AiZheng-Hui LiJuan HeJian-Ping ZuoJi-Kai LiuPublished in: Organic letters (2018)
Two monoterpenoid indole alkaloids, ophiorrhines A (1) and B (2), were obtained from plant Ophiorrhiza japonica BI. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Compounds 1 and 2 possess a novel spirocyclic ring system. Its biosynthesis pathway is proposed. Compound 2 exhibits potent inhibitory activity against concanavalin A (Con A) induced T cell proliferation and lipopolysaccharide (LPS) induced B lymphocyte cell proliferation with IC50 values 13.3 and 7.5 μM, respectively. Compound 1 exhibits significant inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC50 value 18.6 μM.
Keyphrases
- lps induced
- cell proliferation
- inflammatory response
- induced apoptosis
- high resolution
- cell cycle arrest
- cell cycle
- pi k akt
- peripheral blood
- signaling pathway
- molecular docking
- high glucose
- diabetic rats
- cell wall
- electron microscopy
- drug induced
- toll like receptor
- magnetic resonance imaging
- cell death
- oxidative stress
- computed tomography
- crystal structure
- dual energy
- solid state