An Approach to the Core of Lactonamycin.
Philip J ParsonsDaniel R JonesLee J WalshLewis A T AllenAda OnwubikoLewis PreeceJohnathan BoardAndrew J P WhitePublished in: Organic letters (2017)
A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.
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