Tumor cell-released autophagosomes (TRAPs) induce PD-L1-decorated NETs that suppress T-cell function to promote breast cancer pulmonary metastasis.

Xiaohe ZhouChengdong WuXuru WangNing PanXiaotong SunBohao ChenShiya ZhengYiting WeiJing ChenYuyang WuFengjiao ZhuJinpeng ChenHuabiao ChenLi-Xin Wang

Published in: Journal for immunotherapy of cancer (2024)

Our results demonstrate a novel role of TRAPs in the formation of PD-L1-decorated NETs, which may provide a new strategy for early detection and treatment of pulmonary metastasis in patients with breast cancer.

Keyphrases

pulmonary hypertension
reduced graphene oxide
quantum dots
single cell
highly efficient
cell therapy
stem cells
smoking cessation