CCR1 and CCR5 mediate cancer-induced myelopoiesis and differentiation of myeloid cells in the tumor.

Serena Zilio Silvio BicciatoDonald WeedPaolo Serafini

Published in: Journal for immunotherapy of cancer (2022)

Our data support the notion that CCR1 and CCR5 and their ligands are a master immunological hub activated by several tumor derived factors. Activation of this pathway is necessary for the differentiation of MDSCs and protumoral macrophages.

Keyphrases

dendritic cells
regulatory t cells
induced apoptosis
papillary thyroid
cell cycle arrest
immune response
high glucose
diabetic rats
big data
signaling pathway
drug induced
squamous cell
machine learning
data analysis
endoplasmic reticulum stress
artificial intelligence
childhood cancer