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CD19 chimeric antigen receptor-T cells in B-cell leukemia and lymphoma: current status and perspectives.

Mohamad MohtyJordan GauthierFlorent MalardMahmoud AljurfAli BazarbachiChristian ChabanonMohamed A Kharfan-DabajaBipin P SavaniHe HuangSaad KenderianArnon NaglerMiguel-Angel Perales
Published in: Leukemia (2019)
The approval of tisagenlecleucel and axicabtagene ciloleucel represents a breakthrough in the field of immune and cellular therapy for hematologic malignancies. These anti-CD19 chimeric antigen receptor-T cells (CAR) proved to be highly effective in the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) and specific histologic subtypes of B-cell non-Hodgkin lymphomas. This expert review aims to summarize the current available research evidence in this field, with a special focus on the different challenges faced by treating physicians, and we also provide future perspectives.
Keyphrases
  • acute lymphoblastic leukemia
  • current status
  • acute myeloid leukemia
  • diffuse large b cell lymphoma
  • hodgkin lymphoma
  • primary care
  • nk cells
  • bone marrow
  • multiple myeloma
  • clinical practice
  • combination therapy