Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV.
Wouter A van der HeijdenRosanne C van DeurenLisa van de WijerInge C L van den MunckhofMarloes SteehouwerNiels P RiksenMihai G NeteaQuirijn de MastLinos VandekerckhoveRicharda M de VoerAndre J van der VenAlexander HoischenPublished in: The Journal of infectious diseases (2021)
Clonal hematopoiesis, a common age-related phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associated with all-cause mortality, cancer and cardiovascular disease. People with HIV (PWH) are at risk for non-AIDS related comorbidities such as atherosclerotic cardiovascular disease and cancer. In a cross-sectional cohort study, we compared clonal hematopoiesis prevalence in PWH on stable antiretroviral therapy, with prevalence in a cohort of overweight individuals and a cohort of age- and sex-matched population controls. The prevalence of clonal hematopoiesis adjusted for age was increased and clone size was larger in PWH compared to population controls. Clonal hematopoiesis is associated with low CD4 nadir, increased residual HIV-1 transcriptional activity and coagulation factors in PWH. Future studies on the effect of clonal hematopoiesis on the HIV reservoir, and non-AIDS related comorbidities are warranted.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv aids
- hiv infected patients
- cardiovascular disease
- hiv testing
- men who have sex with men
- hepatitis c virus
- risk factors
- gene expression
- hematopoietic stem cell
- papillary thyroid
- transcription factor
- coronary artery disease
- squamous cell
- physical activity
- cell death
- induced apoptosis
- metabolic syndrome
- young adults
- current status
- nk cells