NAD metabolism fuels human and mouse intestinal inflammation.

Romana Raphaela GernerVictoria KlepschSophie MacheinerKathrin ArnhardTimon E AdolphChristoph GranderVerena WieserAlexandra PfisterPatrizia MoserNatascha Hermann-KleiterGottfried BaierHerbert OberacherHerbert TilgAlexander R Moschen

Published in: Gut (2017)

Our data emphasise the importance of NAD immunometabolism for mucosal immunity and highlight FK866-mediated NAMPT blockade as a promising therapeutic approach in acute intestinal inflammation.

Keyphrases

oxidative stress
endothelial cells
liver failure
respiratory failure
electronic health record
induced pluripotent stem cells
big data
drug induced
aortic dissection
acute respiratory distress syndrome