Double-Fold Ortho and Remote C-H Bond Activation/Borylation of BINOL: A Unified Strategy for Arylation of BINOL.
Ranjana BishtJagriti ChaturvediGajanan PandeyBuddhadeb ChattopadhyayPublished in: Organic letters (2019)
A double-fold ortho and remote C-H borylation of BINOL is described. The proposed mechanisms involved electrostatically and sterically directed ortho and remote C-H activation processes, respectively. While B2eg2 (eg = ethylene glycolate) directs the C-H activation at ortho positions, a combination of HBpin and B2pin2 activates remote C-H bonds. The strategy was combined with Suzuki arylation as a one-pot protocol for the rapid synthesis of BINOL derivatives with retention of chirality.
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