Management of venous thromboembolism in patients with cancer.
J J López-NúñezJ Trujillo-SantosManuel MonrealPublished in: Journal of thrombosis and haemostasis : JTH (2018)
Current guidelines for anticoagulant therapy do not so far suggest any form of differentiated approach to cancer patients with venous thromboembolism (VTE). This review article provides an overview of the published literature in cancer patients with VTE, mostly using data from the RIETE registry. Our findings provide some insights into what factors may be used to guide physicians in adapting recommended anticoagulant regimens to the individual patient, as oncologists are increasingly doing with cancer treatments. For instance, patients presenting with deep vein thrombosis (DVT) alone might benefit from curtailing treatment intensity as anticoagulant therapy progresses. The site of cancer also needs to be considered. In patients with incidental PE or splanchnic vein thrombosis, we should be more cautious before prescribing anticoagulant therapy. The optimal duration of anticoagulant therapy is unknown.
Keyphrases
- venous thromboembolism
- direct oral anticoagulants
- papillary thyroid
- atrial fibrillation
- primary care
- squamous cell
- systematic review
- emergency department
- stem cells
- squamous cell carcinoma
- case report
- mesenchymal stem cells
- young adults
- childhood cancer
- high intensity
- big data
- deep learning
- combination therapy
- replacement therapy
- meta analyses