Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP SAA knock-in mouse model of Alzheimer's disease.

Andrés NorambuenaVijay Kumar SagarZhuoying WangPrakash RautZiang FengHorst WallrabeEvelyn PardoTaylor KimShagufta Rehman AlamSong HuAmmasi PeriasamyGeorge S Bloom

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

mice. Pharmacological interventions can rescue AD-related NiMA disruption in vivo.

Keyphrases

mouse model
functional connectivity
resting state
oxidative stress
physical activity
high fat diet induced
cognitive decline
heavy metals
type diabetes
skeletal muscle