Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.
Xu HouFabienne C FieselDominika TrubanMonica Castanedes CaseyWen-Lang LinAlexandra I SotoPawel TacikLinda G RousseauNancy N DiehlMichael G HeckmanOswaldo Lorenzo-BetancorIsidro FerrerJosé M ArbeloJohn C SteeleMatthew J FarrerMario Cornejo-OlivasLuis TorresIgnacio F MataNeill R Graff-RadfordZbigniew K WszolekOwen A RossMelissa E MurrayDennis W DicksonWolfdieter SpringerPublished in: Autophagy (2018)
BLBD: brainstem predominant Lewy body disease; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; DLB: dementia with Lewy bodies; DLBD: diffuse neocortical Lewy body disease; EOPD: early-onset Parkinson disease; GVB: granulovacuolar degeneration body; LB: Lewy body; LBD: Lewy body disease; mitoQC: mitochondrial quality control; nbM: nucleus basalis of Meynert; PD: Parkinson disease; PDD: Parkinson disease with dementia; p-S65-Ub: PINK1-phosphorylated serine 65 ubiquitin; SN: substantia nigra; TLBD: transitional Lewy body disease; Ub: ubiquitin.