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Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells.

Zhiliang BaiStefan LundhDongjoo KimSteven WoodhouseDavid M BarrettRegina M MyersStephan A GruppMarcela V MausCarl H JunePablo G CamaraJ Joseph MelenhorstRong Fan
Published in: Journal for immunotherapy of cancer (2022)
Through integrated multiomics profiling and unbiased canonical pathway analyses, our results unveil heterogeneities in the transcriptional, phenotypic, functional, and metabolic profiles of donor and patient CAR T cells, providing mechanistic basis for ameliorating clinical outcomes and developing next-generation 'off- the-shelf' allogeneic products.
Keyphrases
  • single cell
  • rna seq
  • stem cell transplantation
  • case report
  • high throughput
  • bone marrow
  • gene expression
  • transcription factor
  • cancer therapy
  • hematopoietic stem cell
  • high dose
  • oxidative stress