Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate ENaC: Role in Rapid Renal Responses to Dietary Potassium.
Bidisha SahaWaheed ShabbirEnzo TakagiXin-Peng DuanDeise Carla Almeida Leite DellovaJohn DemkoAnna ManisDominique Loffing-CueniJohannes LoffingMads Vaarby SørensenWen-Hui WangDavid PearcePublished in: Journal of the American Society of Nephrology : JASN (2023)
The mTORC2-SGK1-Nedd4-2-ENaC signaling axis is a key mediator of rapid tubule cell responses to increased plasma [K+] in vivo. The effects of K+ on this signaling module are specific, in that other downstream mTORC2 targets such as PKC and Akt are not acutely affected, and ROMK and BK channels are not activated. These findings provide new insight into the signaling network and ion transport systems that underlie renal responses to K+in vivo.