New insights into the regulation of TGF-β/Smad and MPK signaling pathway gene expressions by nasal allergen and methacholine challenge test in asthma.
Michał Gabriel PanekMichał Seweryn KarbownikKarol Maksymilian GórskiMarcelina KoćwinGrzegorz KardasMateusz MarynowskiPiotr KunaPublished in: Clinical and translational allergy (2022)
Our experiment allows us to conclude that the change in the mRNA expression of the TGF-β1-MPK1/3 and Smad3/6/7 genes occurs after an intranasal allergen and bronchial methacholine challenge.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- allergic rhinitis
- signaling pathway
- genome wide
- genome wide identification
- chronic obstructive pulmonary disease
- pi k akt
- copy number
- lung function
- genome wide analysis
- dna methylation
- induced apoptosis
- gene expression
- oxidative stress
- air pollution
- cystic fibrosis