Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program.

Carlos Jiménez Roberta Antonelli Mariona Nadal-Ribelles Laura Devis-Jauregui Pablo Latorre Carme Solé Marc Masanas Adrià Molero-Valenzuela Aroa Soriano FernandezJosep Sánchez de ToledoDavid Llobet-Navàs Josep Roma Francesc Posas Eulalia de Nadal Soledad Gallego Melcon Lucas Moreno Miguel F Segura

Published in: Molecular cancer (2022)

We report a novel ATPase-independent role for the BAF complex in maintaining an epigenomic program that allows neuroblastoma invasiveness and metastasis, urging for the development of new BAF pharmacological structural disruptors for therapeutic exploitation in metastatic neuroblastoma.

Keyphrases

quality improvement
squamous cell carcinoma
small cell lung cancer
gene expression
dna damage
transcription factor
genome wide
endoplasmic reticulum