LDL-cholesterol and PCSK9 in patients with familial hypercholesterolemia: influence of PCSK9 variants under lipid-lowering therapy.

Masato HamasakiNaoki SakaneKazuo HaraKazuhiko Kotani

Published in: Journal of clinical laboratory analysis (2021)

The LDL-C-PCSK9 correlation is suggested to be retained in FH patients with GOF variants of PCSK9 even under LLT, and these variants can be used as molecular markers for additional treatment with statins in FH patients.

Keyphrases

low density lipoprotein
copy number
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
cardiovascular disease
peritoneal dialysis
stem cells
gene expression
single molecule
bone marrow
combination therapy