Salt Sensitivity of Blood Pressure and Aldosterone: Interaction Between the Lysine-specific Demethylase 1 Gene, Sex, and Age.
Wasita Warachit ParksookMahyar HeydarpourShadi K GholamiJames M LutherPaul N HopkinsLuminita H PojogaJonathan S WilliamsPublished in: The Journal of clinical endocrinology and metabolism (2022)
SSBP associated with LSD1 risk allele status is driven by women with a depleted estrogen state. Mechanisms related to a resistance to develop SSBP in females are uncertain but may relate to an estrogen-modulating effect on mineralocorticoid receptor (MR) activation and/or LSD1 epigenetic regulation of the MR.
Keyphrases
- blood pressure
- estrogen receptor
- contrast enhanced
- magnetic resonance
- copy number
- genome wide
- hypertensive patients
- signaling pathway
- heart rate
- magnetic resonance imaging
- computed tomography
- type diabetes
- genome wide identification
- metabolic syndrome
- dna methylation
- binding protein
- skeletal muscle
- adipose tissue
- insulin resistance