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Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura.

Malay Kumar BasuFelipe MassicanoLijia YuKonstantine HalkidisVikram PillaiWenjing CaoLiang ZhengX Long Zheng
Published in: Thrombosis and haemostasis (2020)
 Altered glycosylation may affect the disease onset and progression in various ways: it may predispose patients to produce ADAMTS13 autoantibodies or affect their binding properties; it may also alter clearance kinetics of hemostatic and inflammatory proteins. Together, our findings provide novel insights into plausible mechanisms underlying the pathogenesis of iTTP.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • systemic lupus erythematosus
  • peritoneal dialysis
  • oxidative stress
  • prognostic factors
  • genome wide
  • gene expression
  • dna methylation