Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals.

Sam KintWim TrypsteenWard De SpiegelaereEva MalatinkovaSabine Kinloch-de LoesTim De MeyerWim Van CriekingeLinos Vandekerckhove

Published in: Clinical epigenetics (2020)

Contrasting in vitro studies, our results indicate that intragenic hypermethylation of HIV-1 proviral DNA is an underestimated factor in viral control in HIV-1-infected individuals, showing the importance of analyzing the complete proviral genome in future DNA methylation studies.

Keyphrases

hiv infected
antiretroviral therapy
dna methylation
genome wide
human immunodeficiency virus
hiv positive
sars cov
hiv aids
hiv testing
gene expression
case control
hepatitis c virus
men who have sex with men
circulating tumor
transcription factor
current status
cell free
south africa