Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus.
Yue FeiQi LiuNa PengGuocan YangZiwei ShenPan HongShengjun WangKe RuiDawei CuiPublished in: Journal of immunology research (2022)
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple systems. Its clinical manifestation varies across patients, from skin mucosa to multiorgan damage to severe central nervous system involvement. The exosome has been shown to play an important role in the pathogenesis of autoimmune diseases, including SLE. We review the recent knowledge of exosomes, including their biology, functions, mechanism, and standardized extraction and purification methods in SLE, to highlight potential therapeutic targets for SLE.
Keyphrases
- systemic lupus erythematosus
- disease activity
- end stage renal disease
- mesenchymal stem cells
- stem cells
- ejection fraction
- newly diagnosed
- healthcare
- chronic kidney disease
- multiple sclerosis
- prognostic factors
- oxidative stress
- peritoneal dialysis
- drug induced
- early onset
- risk assessment
- cerebrospinal fluid
- patient reported outcomes
- high school