Developing DPYD Genotyping Method for Personalized Fluoropyrimidines Therapy.

Betty Y L WongZhenyu LiMichael Jonathon RaphaelCarlo De AngelisDavid M HwangLei Fu

Published in: The journal of applied laboratory medicine (2023)

A robust multiplex AS-PCR assay was developed to rapidly detect 5 variants in the DPYD gene. It can be used for screening DPYD variants to identify patients with increased risk of toxicity when prescribed fluoropyrimidine therapy.

Keyphrases

copy number
high throughput
genome wide
oxidative stress
stem cells
dna methylation
bone marrow
transcription factor
genetic diversity