Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.

Michael WinklehnerJan BauerVerena EndmayrCarmen SchwaigerGerda RickenMasakatsu MotomuraShunsuke YoshimuraHiroshi ShintakuKinya IshikawaYukio TsuuraTakahiro IizukaTakanori YokotaTakashi IriokaRomana Höftberger

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

Anti-Yo-PCD showed characteristic features of a T cell-mediated pathology, whereas this was not observed in 1 case of anti-P/Q-VGCC-PCD. Our findings support a pathogenic role of anti-P/Q-VGCC autoantibodies in causing neuronal dysfunction, probably due to altered synaptic transmission resulting in calcium dysregulation and subsequent PC death. Because disease progression may lead to irreversible PC loss, anti-P/Q-VGCC-PCD patients could benefit from early oncologic and immunologic therapies.

Keyphrases

systemic lupus erythematosus
end stage renal disease
newly diagnosed
prostate cancer
oxidative stress
rectal cancer
blood brain barrier
minimally invasive
brain injury
radical prostatectomy