Facile Access to 2-Selenoxo-1,2,3,4-tetrahydro-4-quinazolinone Scaffolds and Corresponding Diselenides via Cyclization between Methyl Anthranilate and Isoselenocyanates: Synthesis and Structural Features.
Vladimir K OsmanovEvgeniy V ChipinskyVictor N KhrustalevKonstantin Yu ZhizhinRizvan Kamiloglu AskerovAlexander O ChizhovGalina N BorisovaAlexander V BorisovMaria M GrishinaMargarita N KurasovaAnatoly A KirichukAlexander S PeregudovAndreii S KritchenkovAlexander G TskhovrebovPublished in: Molecules (Basel, Switzerland) (2022)
A practical method for the synthesis of 2-selenoxo-1,2,3,4-tetrahydro-4-quinazolinone was reported. The latter compounds were found to undergo facile oxidation with H 2 O 2 into corresponding diselenides. Novel organoselenium derivatives were characterized by the 1 H, 77 Se, and 13 C NMR spectroscopies, high-resolution electrospray ionization mass spectrometry, IR, elemental analyses (C, H, N), and X-ray diffraction analysis for several of them. Novel heterocycles exhibited multiple remarkable chalcogen bonding (ChB) interactions in the solid state, which were studied theoretically.
Keyphrases
- solid state
- high resolution
- mass spectrometry
- quantum dots
- reduced graphene oxide
- visible light
- liquid chromatography
- highly efficient
- metal organic framework
- hydrogen peroxide
- gas chromatography
- tandem mass spectrometry
- capillary electrophoresis
- magnetic resonance
- electron microscopy
- high performance liquid chromatography
- high speed
- gold nanoparticles
- crystal structure
- magnetic resonance imaging
- computed tomography
- nitric oxide
- ms ms
- dual energy
- data analysis