Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits.
Huynh Nga NguyenSarah L UllevigJohn D ShortLuxi WangYong Joo AhnReto AsmisPublished in: Antioxidants (Basel, Switzerland) (2021)
Ursolic acid (UA) is a well-studied natural pentacyclic triterpenoid found in herbs, fruit and a number of traditional Chinese medicinal plants. UA has a broad range of biological activities and numerous potential health benefits. In this review, we summarize the current data on the bioavailability and pharmacokinetics of UA and review the literature on the biological activities of UA and its closest analogues in the context of inflammation, metabolic diseases, including liver and kidney diseases, obesity and diabetes, cardiovascular diseases, cancer, and neurological disorders. We end with a brief overview of UA's main analogues with a special focus on a newly discovered naturally occurring analogue with intriguing biological properties and potential health benefits, 23-hydroxy ursolic acid.
Keyphrases
- public health
- healthcare
- cardiovascular disease
- mental health
- type diabetes
- molecular docking
- human health
- metabolic syndrome
- health promotion
- weight loss
- squamous cell carcinoma
- insulin resistance
- body mass index
- risk assessment
- young adults
- structure activity relationship
- glycemic control
- big data
- artificial intelligence
- molecular dynamics simulations
- cardiovascular risk factors
- high fat diet induced
- data analysis
- drug induced
- solid state