FYN/TOPK/HSPB1 axis facilitates the proliferation and metastasis of gastric cancer.

SanFei PengYuHan YinYiZheng ZhangFeng ZhuGe YangYang Fu

Published in: Journal of experimental & clinical cancer research : CR (2023)

FYN directly binds to TOPK in GC cells and phosphorylates TOPK at the Y272, which leads to proliferation and metastasis of GC. FYN-TOPK axis facilitates GC progression by phosphorylating HSPB1. Collectively, our study elucidates the pivotal role of the FYN-TOPK-HSPB1 cascade in GC.

Keyphrases

heat shock protein
heat shock
gas chromatography
signaling pathway
induced apoptosis
cell cycle arrest
cell death
cell proliferation
pi k akt
heat stress