Colonic hypersensitivity and low-grade inflammation in a spontaneous animal model for functional gastrointestinal disorders.

Mathieu MeleineAlison AccarieLucas WautersJoran TothGuillaume GourcerolJan TackRicard FarréTim Vanuytsel

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

We demonstrated a lamina propria eosinophil and mast cell infiltration preceding visceral hypersensitivity in the colon of the BBDP-N rat, reminiscent of patients with FGID. These findings help elucidating pathogenetic pathways in FGID and further validate the BBDP-N rat as an attractive model to study pathophysiology and therapy of FGID.

Keyphrases

low grade
oxidative stress
high grade
drug induced
insulin resistance
type diabetes
stem cells
metabolic syndrome
bone marrow
adipose tissue
ulcerative colitis